Methylamine → 3-aminooxy-2,2,N-trimethyl-propionamide

HRID 20762ノート

反応式

HRID 20762 の反応式
C[O:2][C:3](=O)[C:4]([CH3:19])([CH3:18])[CH2:5][O:6][N:7]1C(=O)C2C(=CC=CC=2)C1=O.[CH3:21][NH2:22]>CO>[NH2:7][O:6][CH2:5][C:4]([CH3:19])([CH3:18])[C:3]([NH:22][CH3:21])=[O:2]

参加物

4

反応物 2

HCID 6329MethylamineHCID 593480263-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester

生成物 1

HCID 553004123-aminooxy-2,2,N-trimethyl-propionamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

To 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester (800 mg) obtained in Step A was added a 40% solution of methylamine in methanol (6 ml), and the mixture was stirred at 60° C. for 13 hours. After the reaction mixture was concentrated under reduced pressure, dichloromethane was added to the residue, and insoluble matter was filtered. The filtrate was concentrated, and the residue was purified by silica gel column chromatography to give the title compound (202 mg).

後処理

  1. concentrationAfter the reaction mixture was concentrated under reduced pressure, dichloromethane
  2. additionwas added to the residue, and insoluble matter
  3. filtrationwas filtered
  4. concentrationThe filtrate was concentrated
  5. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-d43277e76df54f6e872b18dd2e300859
出典データセット
uspto-grants-2010_06
特許番号
US07745663B2

反応ノート

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