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Diethyl Oxalate → Ethyl 2-oxo-2-(10-oxotricyclo[6.2.2.02,7]dodeca-2,4,6-trien-9-yl)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Oxalate | HCID 7268 | — |
| 反応物 | Hexamethyldisilazane | HCID 13838 | — |
| 反応物 | 1,4-Ethanonaphthalen-2(1H)-one, 3,4-dihydro- | HCID 582596 | — |
| 反応物 | 10-(2,4-Dichlorophenyl)-10,11-diazatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6,9(13),11-pentaene-12-carboxylic acid | HCID 86623337 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 生成物 | Ethyl 2-oxo-2-(10-oxotricyclo[6.2.2.02,7]dodeca-2,4,6-trien-9-yl)acetate | HCID 67029310 | — |
反応手順
The title product was prepared by a procedure similar to that described for step 1 of intermediate 1. From tricyclo[6.2.2.02,7]dodeca-2,4,6-trien-9-one [prepared by one of the methods available in the art of organic synthesis, e.g., as described in Hales et. al. Tetrahedron, 1995, 51, 7777-7790] (2.5 g, 14.53 mmol), hexamethyldisilazane (4.9 ml, 23.2 mmol), 2.34M n-BuLi (10 ml, 23.4 mmol) and diethyl oxalate (3.18 ml, 21.18 mmol) the desired product was obtained (2.3 g, 63%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07923465B2 |
| 出典データセット | uspto-grants-2011_04 |
| ORD ID | ord-aead04f9196a4ba889d38cebd8cb4036 |
| 出典メモ | uspto-grants-2011_04 |