Triphenylphosphine → HCID 57849580、化合物

HRID 2076799ノート

反応式

HRID 2076799 の反応式
[C:1]([O:5][C:6](=[O:20])[N:7]([CH2:17][CH2:18][OH:19])[CH2:8][C@@H:9](O)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CCOC(/N=N/C(OCC)=O)=O>C1(C)C=CC=CC=1>[C:1]([O:5][C:6]([N:7]1[CH2:17][CH2:18][O:19][C@@H:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8]1)=[O:20])([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 11776TriphenylphosphineHCID 5462977Diethyl azodicarboxylateHCID 57849526HCID 57849526、化合物

生成物 1

HCID 57849580HCID 57849580、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

3 g of (S)-(2-Hydroxy-ethyl)-(2-hydroxy-2-phenyl-ethyl)-carbamic acid tert-butyl ester and 0.327 g of triphenylphosphine were dissolved in 53.3 mL toluene. 0.217 g of diethylazodicarboxylate in 5.4 mL toluene was added dropwise to the resulting solution at room temperature under argon atmosphere and the mixture was stirred overnight. The solvent was removed in vacuo and the material purified by column chromatography.

後処理

  1. customThe solvent was removed in vacuo
  2. customthe material purified by column chromatography

出典と根拠

ORDレコード
ord-429c779d6e154ac886d5aaa0e1d71f96
出典データセット
uspto-grants-2011_04
特許番号
US07928103B2

反応ノート

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