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4-Amino-5-pyrimidinecarboxamide → HCID 135923523、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Amino-5-pyrimidinecarboxamide | HCID 818212 | — |
| 反応物 | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| 反応物 | (2-m-Tolyl-ethoxy)-acetic acid methyl ester | HCID 67099145 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 135923523 | HCID 135923523 | — |
反応手順
In analogy to example 3.3, 4-amino-5-pyrimidinecarboxamide and (2-m-tolyl-ethoxy)-acetic acid methyl ester (prepared from 2-m-tolyl-ethanol [1875-89-4] in analogy to example 3.1-3.2) reacted in the presence of LiHMDS in THF to yield the title compound (after purification of the crude product with column chromatography (silica gel, EtOAc/MeOH) and crystallization from TBME) as white solid. MS: m/e=295.5 [M−H−].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07928106B2 |
| 出典データセット | uspto-grants-2011_04 |
| ORD ID | ord-ca34c62bdfdf40b38c1e7d6eb9faadd6 |
| 出典メモ | uspto-grants-2011_04 |