Dimethyl Sulfoxide → HCID 11949627、化合物

HRID 2077083ノート

反応式

HRID 2077083 の反応式
[Cl:1][C:2]1[N:9]=[C:8]([NH:10][C:11]2[CH:15]=[C:14]([CH3:16])[NH:13][N:12]=2)[CH:7]=[C:6]([CH3:17])[C:3]=1[C:4]#[N:5].[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH2:25][CH2:26][NH2:27])[CH:19]=1.C(=O)([O-])O.[Na+].CS(C)=O>O>[ClH:1].[ClH:1].[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH2:25][CH2:26][NH:27][C:2]2[N:9]=[C:8]([NH:10][C:11]3[CH:15]=[C:14]([CH3:16])[NH:13][N:12]=3)[CH:7]=[C:6]([CH3:17])[C:3]=2[C:4]#[N:5])[CH:19]=1

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 516892Sodium BicarbonateHCID 97937933-(2-Aminoethoxy)pyridineHCID 119835452-chloro-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile

生成物 1

HCID 11949627HCID 11949627、化合物収率 138.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
130 °C

実験手順

Compound A (13 g, 53 mmol), 2-(pyridin-3-yloxy)ethylamine (11 g, 80 mmol) and sodium hydrogencarbonate (45 g) were added to DMSO (130 ml), and the mixture was stirred at 130° C. for 20 hr. After stirring, the reaction mixture was added to cold water, and insoluble substance was filtrated (20 g). This was converted to hydrochloride to give the object compound of 2-(2-(pyridin-3-yloxy)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile dihydrochloride (15.5 g).

後処理

  1. stirringAfter stirring
  2. filtrationwas filtrated (20 g)

出典と根拠

ORDレコード
ord-eb8fd9396688484d9adf5635fd6883e7
出典データセット
uspto-grants-2011_04
特許番号
US07928126B2

反応ノート

読み込み中…