Ethylamine → N-ethyl-4-methoxybenzenesulfonamide

HRID 2077510ノート

反応式

HRID 2077510 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[CH2:13]([NH2:15])[CH3:14]>C(Cl)Cl>[CH2:13]([NH:15][S:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)(=[O:11])=[O:10])[CH3:14]

参加物

4

反応物 2

HCID 6341EthylamineHCID 74014-Methoxybenzenesulfonyl chloride

生成物 1

HCID 4453230N-ethyl-4-methoxybenzenesulfonamide収率 112%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

4-Methoxybenzene-1-sulfonyl chloride (619.5 mg, 2.999 mmol) was dissolved in DCM (10 mL) and ethylamine (4.6 mL, 2.0 M in THF, 9.2 mmol) was added, and the reaction flask was put in a water bath and stirred under nitrogen. After stirring at RT over the weekend, the suspension was filtered, and the solid was washed with DCM. The filtrate was concentrated and dried under high vacuum to provide N-ethyl-4-methoxybenzenesulfonamide (723 mg, 89% yield). MS (ESI pos. ion) m/z: 216 (MH+). Calculated exact mass for C9H13NO3S: 215.

後処理

  1. customthe reaction flask was put in a water bath
  2. stirringAfter stirring at RT over the weekend
  3. filtrationthe suspension was filtered
  4. washthe solid was washed with DCM
  5. concentrationThe filtrate was concentrated
  6. customdried under high vacuum

出典と根拠

ORDレコード
ord-5cbd9edec7f444d98af3a89e42fafd73
出典データセット
uspto-grants-2011_04
特許番号
US07928140B2

反応ノート

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