化工社化工社 化学情報印刷レポート · 研究参考用
Methylamine → 5-Bromo-N-methyl-3-nitropyridin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 5-Bromo-2-chloro-3-nitropyridine | HCID 7019412 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-Bromo-N-methyl-3-nitropyridin-2-amine | HCID 10868149 | — |
反応手順
5-bromo-2-chloro-3-nitropyridine (456 mg, 1920 μmol) was dissolved in MeOH (6.0 ml) and methylamine, 2.0 M solution in tetrahydrofuran (2.5 ml, 5.0 mmol) was added. The reaction was stirred at room temperature for 6 hours, allowed to stand at room temperature overnight, and then concentrated. material was taken directly to the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07928140B2 |
| 出典データセット | uspto-grants-2011_04 |
| ORD ID | ord-477fb39ca8fe4324914ee8e5e98c1828 |
| 出典メモ | uspto-grants-2011_04 |