Water → N-(5-Bromothiazolo[5,4-b]pyridin-2-yl)acetamide

HRID 2077539

反応式

HRID 2077539 の反応式
Br[C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[C:4]([Br:9])[N:3]=1.[C:10]([N:13]=[C:14]=[S:15])(=[O:12])[CH3:11].O>CC(C)=O>[Br:9][C:4]1[N:3]=[C:2]2[S:15][C:14]([NH:13][C:10](=[O:12])[CH3:11])=[N:8][C:7]2=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 962WaterHCID 128851Acetyl isothiocyanateHCID 8176783-Amino-2,6-dibromopyridine

生成物 1

HCID 56763853N-(5-Bromothiazolo[5,4-b]pyridin-2-yl)acetamide収率 121.2%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
67.5 °C

実験手順

2,6-dibromopyridin-3-amine (4.235 g, 16.8 mmol) was dissolved in acetone and acetyl isothiocyanate (1.85 ml, 21.0 mmol) was added. The flask was fit with a reflux condensor and placed in a preheated oil bath (65-70° C.) and stirred under nitrogen for 2.5 hours. Then, the reaction was cooled to room temperature, poured into water, and filtered. The solid was washed with water, saturated sodium bicarbonate, and water again, and then collected and dried under high vacuum to afford N-(5-bromothiazolo[5,4-b]pyridin-2-yl)acetamide (5.54 g, Yield >100%).

後処理

  1. customplaced in a preheated oil bath
  2. temperatureThen, the reaction was cooled to room temperature
  3. filtrationfiltered
  4. washThe solid was washed with water, saturated sodium bicarbonate, and water again
  5. customcollected
  6. customdried under high vacuum

出典と根拠

ORDレコード
ord-b5afa79e6b4742d984f01cd24eb5d381
出典データセット
uspto-grants-2011_04
特許番号
US07928140B2

関連ノート

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