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Acetone → 2-Methyl-2-piperidin-1-ylpropanenitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetone | HCID 180 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | Piperidine, hydrochloride (1:1) | HCID 2723721 | — |
| 反応物 | 1-(Dimethylamino)cyclopentanecarbonitrile | HCID 10773049 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Methyl-2-piperidin-1-ylpropanenitrile | HCID 288882 | 77% |
反応手順
The title compound (2.33 g, 77%) was prepared from piperidine hydrochloride (2.43 g, 20 mmol), acetone (1.16 g, 20 mmol) and potassium cyanide (1.30 g, 20 mmol) in water (10 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 1.46 (2H, m), 1.50 (6H, s), 1.63 (4H, m), 2.59 (4H, m).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745642B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-512a6c3f8abe44da91d6031f77031de6 |
| 出典メモ | uspto-grants-2010_06 |