化工社化工社 化学情報印刷レポート · 研究参考用
2-Methyl-2-piperidin-1-ylpropanenitrile → (+/-)2-Methyl-1-phenyl-2-(1-piperidinyl)-1-propanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methyl-2-piperidin-1-ylpropanenitrile | HCID 288882 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | {1-[Amino(phenyl)methyl]cyclopentyl}dimethylamine | HCID 11521393 | — |
| 反応物 | HCID 178506676 | HCID 178506676 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Butyl ether | HCID 8909 | — |
| 生成物 | (+/-)2-Methyl-1-phenyl-2-(1-piperidinyl)-1-propanamine | HCID 199304 | 56% |
反応手順
The title compound (1.16 g, 56%) was prepared from 2-methyl-2-(1-piperidinyl)propanenitrile D7 (1.30 g, 8.6 mmol), and phenyllithium in dibutylether (5.2 ml of a 1.8M solution; 9.4 mmol) in THF (15 ml), followed by reaction with sodium borohydride (0.975 g, 25.7 mmol) in methanol (20 ml) in a similar manner to that described in D2. 1H NMR (CDCl3) δ: 0.76 (3H, s), 0.91 (3H, s), 1.44 (2H, m), 1.54-1.65 (4H, m), 1.95 (2H, m), 2.57 (4H, m), 4.19 (1H, s), 7.20-7.31 (3H, m), 7.40 (2H, m).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745642B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-246ca7faebb947818f80c9620a83e184 |
| 出典メモ | uspto-grants-2010_06 |