Hydrochloric Acid → (2-Allyl-4-bromo-6-methoxyphenoxy)triisopropylsilane

HRID 2079213ノート

反応式

HRID 2079213 の反応式
C(O)(=O)C.FC1C(OCCF)=CC(OC)=CC=1C(NC1C=CC(C(N)=N)=CC=1)C1NC(=O)N(C2N=CC=CN=2)N=1.[CH2:41]([C:44]1[CH:49]=[C:48]([Br:50])[CH:47]=[C:46]([O:51][CH3:52])[C:45]=1[OH:53])[CH:42]=[CH2:43].N1C=CN=C1.Cl[Si:60]([CH:67]([CH3:69])[CH3:68])([CH:64]([CH3:66])[CH3:65])[CH:61]([CH3:63])[CH3:62].Cl>CN(C=O)C.C(OCC)(=O)C>[CH2:41]([C:44]1[CH:49]=[C:48]([Br:50])[CH:47]=[C:46]([O:51][CH3:52])[C:45]=1[O:53][Si:60]([CH:67]([CH3:69])[CH3:68])([CH:64]([CH3:66])[CH3:65])[CH:61]([CH3:63])[CH3:62])[CH:42]=[CH2:43]

参加物

8

反応物 5

HCID 313Hydrochloric AcidHCID 795ImidazoleHCID 139400Triisopropylsilyl chlorideHCID 574077562-Allyl-4-bromo-6-methoxyphenolHCID 1363662624-({[2-fluoro-3-(2-fluoroethoxy)-5-methoxyphenyl]-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl}amino)benzamidine acetate

生成物 1

HCID 67097015(2-Allyl-4-bromo-6-methoxyphenoxy)triisopropylsilane

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
50 °C

実験手順

After dissolving 3g of 2-allyl-4-bromo-6-methoxyphenol in 10 ml of DMF, 1.3 g of imidazole and 2g of chlorotriisopropylsilane were added and the mixture was stirred at 50° C. for 4 hours. Next, 1N hydrochloric acid was added to the reaction mixture and extraction was performed with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate. The desiccating agent was filtered off, and the filtrate was concentrated under reduced pressure to give (2-allyl-4-bromo-6-methoxyphenoxy)triisopropylsilane.

後処理

  1. additionwere added
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  3. filtrationThe desiccating agent was filtered off
  4. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-f6db1aa0408a43998fbacdfc851c242e
出典データセット
uspto-grants-2011_04
特許番号
US07928228B2

反応ノート

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