化工社化工社 化学情報印刷レポート · 研究参考用
Sodium borohydride → (+/-)1-[Amino(phenyl)methyl]-N,N-diethylcyclopentanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | {1-[Amino(phenyl)methyl]cyclopentyl}dimethylamine | HCID 11521393 | — |
| 反応物 | 1-(Diethylamino)cyclopentanecarbonitrile | HCID 24276761 | — |
| 反応物 | HCID 178506676 | HCID 178506676 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Butyl ether | HCID 8909 | — |
| 生成物 | (+/-)1-[Amino(phenyl)methyl]-N,N-diethylcyclopentanamine | HCID 59347816 | 47% |
反応手順
The title compound (0.45 g, 47%) was prepared from 1-(diethylamino)cyclopentane carbonitrile D11 (0.65 g, 3.9 mmol), and phenyllithium in dibutylether (2.4 ml of a 1.8M solution; 4.3 mmol) in THF (4 ml), followed by reaction with sodium borohydride (0.445 g, 11.7 mmol) in methanol (4 ml) in a similar manner to that described in D2. 1H NMR (CDCl3) δ: 0.42 (1H, m), 1.10 (6H, m), 1.35 (3H, m), 1.55 (1H, m), 1.66 (2H, m), 1.80-2.08 (3H, m), 2.53-2.70 (4H, m), 4.22 (1H, s), 7.20-7.31 (3H, m), 7.47 (2H, m).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745642B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-4d59e9db98e74fe08c9c500566141da9 |
| 出典メモ | uspto-grants-2010_06 |