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Cyclopentanone → 1-(1-Azetidinyl)cyclopentanecarbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclopentanone | HCID 8452 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | 1-(Dimethylamino)cyclopentanecarbonitrile | HCID 10773049 | — |
| 反応物 | Azetidine hydrochloride | HCID 12308726 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-(1-Azetidinyl)cyclopentanecarbonitrile | HCID 59347779 | 43% |
反応手順
The title compound (1.29 g, 43%) was prepared from azetidine hydrochloride (1.85 g, 20 mmol), cyclopentanone (1.68 g, 20 mmol) and potassium cyanide (1.30 g, 20 mmol) in water (10 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 1.70-1.82 (6H, m), 1.86 (2H, m), 2.07 (2H, quin, J=7 Hz), 3.32 (4H, t, J=7 Hz).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745642B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-c1121d5546834bab92e2bff97a8f4126 |
| 出典メモ | uspto-grants-2010_06 |