Urea → HCID 178517453、化合物

HRID 2079624

反応式

HRID 2079624 の反応式
[NH2:1][C:2]1[C:7](F)=[CH:6][C:5](Br)=[CH:4][C:3]=1[CH2:10]O.[NH2:12][C:13](N)=[O:14]>O>[OH:14][C:13]1[N:12]=[CH:10][C:3]2[C:2](=[CH:7][CH:6]=[CH:5][CH:4]=2)[N:1]=1

参加物

4

反応物 2

HCID 1176UreaHCID 54312525(2-Amino-5-bromo-3-fluorophenyl)methanol

生成物 1

HCID 178517453HCID 178517453、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
175 °C

実験手順

A mixture of (2-amino-5-bromo-3-fluorophenyl)methanol (5.6 g, 23.7 mmol, obtained from step 3) and urea (21 g, 15 equiv.) was heated to 175° C. with vigorous stirring for 15 min. The reaction was cooled to room temperature and water was added. The solid was collected by filtration. Air-dried to give 2-hydroxyquinazoline as a light brown solid.

後処理

  1. temperatureThe reaction was cooled to room temperature
  2. filtrationThe solid was collected by filtration
  3. customAir-dried

出典と根拠

ORDレコード
ord-486e6bc52795484eb35f0ae084caf42b
出典データセット
uspto-grants-2011_04
特許番号
US07932262B2

関連ノート

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