関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Urea | HCID 1176 | — |
| 反応物 | (2-Amino-5-bromo-3-chlorophenyl)methanol | HCID 67080684 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 178517453 | HCID 178517453 | — |
反応手順
A mixture of (2-amino-5-bromo-3-chlorophenyl)methanol (3.3 g, obtained from step 3) and urea (10.5 g, 15 equiv.) was heated to 180° C. with vigorous stirring for 1 hr. The reaction was cooled to room temperature and water was added. The solid was collected by filtration. Air-dried to give 2-hydroxyquinazoline as a yellow powder (2.18 g, crude). ES/MS m/z 259/261 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07932262B2 |
|---|
| 出典データセット | uspto-grants-2011_04 |
|---|
| ORD ID | ord-aa91e9504bab4eaa9adb9c8601ef4982 |
|---|
| 出典メモ | uspto-grants-2011_04 |
|---|
