Sulfanilamide → 4-[[8-Bromo-6-(trifluoromethyl)-2-quinazolinyl]amino]benzenesulfonamide

HRID 2079629ノート

反応式

HRID 2079629 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:13]([F:16])([F:15])[F:14])[CH:5]=[C:6]2[C:11]=1[N:10]=[C:9](Cl)[N:8]=[CH:7]2.[S:17]([NH2:27])(=[O:26])([C:19]1[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][CH:20]=1)=[O:18]>CC(O)C>[Br:1][C:2]1[CH:3]=[C:4]([C:13]([F:16])([F:15])[F:14])[CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([NH:25][C:22]1[CH:23]=[CH:24][C:19]([S:17]([NH2:27])(=[O:18])=[O:26])=[CH:20][CH:21]=1)[N:8]=[CH:7]2

参加物

4

反応物 2

HCID 5333SulfanilamideHCID 59199251HCID 59199251、化合物

生成物 1

HCID 250160044-[[8-Bromo-6-(trifluoromethyl)-2-quinazolinyl]amino]benzenesulfonamide

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

反応条件

温度
110 °C

実験手順

To a 0.30 M solution of 8-bromo-2-chloro-6-(trifluoromethyl)quinazoline in 2-propanol was added sulfanilamide (1.0 eq). The reaction was stirred at 110° C. for 14 h. The hydrochloride was collected by vacuum filtration and then stirred in aqueous sodium bicarbonate. The solid was collected by vacuum filtration and rinsed with water. The light yellow solid was dried in a desiccator to give 343 mg of the desired product. ES/MS m/z 447, 449 (MH+).

後処理

  1. filtrationThe hydrochloride was collected by vacuum filtration
  2. stirringstirred in aqueous sodium bicarbonate
  3. filtrationThe solid was collected by vacuum filtration
  4. washrinsed with water
  5. customThe light yellow solid was dried in a desiccator

出典と根拠

ORDレコード
ord-0ded3928daca4d30a4e71ee1571a8a08
出典データセット
uspto-grants-2011_04
特許番号
US07932262B2

反応ノート

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