(2-Amino-3-bromo-5-fluorophenyl)methanol → 2-Amino-3-bromo-5-fluorobenzaldehyde
反応式
[NH2:1][C:2]1[C:7]([Br:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[CH2:10][OH:11]>ClCCl.[O-2].[Mn+4].[O-2]>[NH2:1][C:2]1[C:7]([Br:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[CH:10]=[O:11]参加物
4
実験手順
Manganese (IV) oxide (5 eq) was added to a 0.2M solution of (2-amino-3-bromo-5-fluorophenyl)methanol in dichloromethane. The suspension was stirred at ambient temperature under Argon for 12 h. The reaction mixture was filtered through celite and filter cake was washed with dichloromethane. The combined filtrate was concentrated to give brown color solid. ES/MS m/z 218/220 (MH+).
後処理
- filtrationThe reaction mixture was filtered through celite
- filtrationfilter cake
- washwas washed with dichloromethane
- concentrationThe combined filtrate was concentrated
- customto give brown color solid
出典と根拠
- ORDレコード
- ord-19cd4c8288114f409ab813dbb539bfaf
- 出典データセット
- uspto-grants-2011_04
- 特許番号
- US07932262B2
反応ノート
読み込み中…