1,1-Dimethylethyl 6-(2-quinolinylamino)-3-azabicyclo[3.1.0]hexane-3-carboxylate → HCID 43599085、化合物
反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[NH:11][CH:12]1[CH:17]2[CH:13]1[CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16]2>Cl.O1CCOCC1>[CH:13]12[CH:12]([NH:11][C:2]3[CH:3]=[CH:4][C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[N:1]=3)[CH:17]1[CH2:16][NH:15][CH2:14]2参加物
4
実験手順
tert-Butyl 6-(quinolin-2-ylamino)-3-azabicyclo[3.1.0]hexane-3-carboxylate (320 mg, 0.98 mmol) was stirred in 4M HCl in dioxane (2 ml) at r.t. under N2 for 15 min. The solvent was then removed in vacuo and the residue dried under high-vacuum and used in the next step without further purification. LCMS purity 91%, m/z 226 [M+H]+.
後処理
- customThe solvent was then removed in vacuo
- customthe residue dried under high-vacuum
- customused in the next step without further purification
出典と根拠
- ORDレコード
- ord-2dcd32c3ced94f348897428525960df5
- 出典データセット
- uspto-grants-2011_04
- 特許番号
- US07932246B2
反応ノート
読み込み中…