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4-(1-isopropyl-6-nitro-1H-indol-3-yl)-benzonitrile → 4-(6-amino-1-isopropyl-1H-indol-3-yl)-benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(1-isopropyl-6-nitro-1H-indol-3-yl)-benzonitrile | HCID 57442194 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Platinum oxide (PtO) | HCID 82844 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(6-amino-1-isopropyl-1H-indol-3-yl)-benzonitrile | HCID 57442201 | 99.7% |
反応手順
Method E Placc 4-(1-isopropyl-6-nitro-1H-indol-3-yl)-benzonitrile (4, R1=i-Pr, R3=4-benzonitrile) 250 mg, 0.82 mmol) in a 50 mL flask and add a suspension of platinum (II) oxide (16 mg) in tetrahydrofuran (9 mL). Place the reaction under 1 atmosphere of hydrogen and stir until the starting material is consumed. Filter through a celite pad and wash the pad with ethyl acetate (50 mL). Concentrate the combined filtrates to give 225.0 mg of the title compound (99%). LRMS (API ES+)=276.0 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07932284B2 |
| 出典データセット | uspto-grants-2011_04 |
| ORD ID | ord-91566e7c6935422598c04403973d2157 |
| 出典メモ | uspto-grants-2011_04 |