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Riboflavin → 5-(6-amino-1-isopropyl-1H-indol-3-yl)-pyridine-2-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Riboflavin | HCID 493570 | — |
| 反応物 | 4-(1-isopropyl-6-nitro-1H-indol-3-yl)-benzonitrile | HCID 57442194 | — |
| 反応物 | 4-(6-amino-1-isopropyl-1H-indol-3-yl)-benzonitrile | HCID 57442201 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 触媒 | Platinum oxide (PtO) | HCID 82844 | — |
| 生成物 | 5-(6-amino-1-isopropyl-1H-indol-3-yl)-pyridine-2-carbonitrile | HCID 67101189 | — |
反応手順
Method F This compound can be prepared from 5-(1-isopropyl-6-nitro-1H-indol-3-yl)-pyridine-2-carbonitrile (4, R1=i-Pr, R3=5-(2-cyanopyridine)) in a manner substantially similar to that described immediately above for 4-(6-amino-1-isopropyl-1H-indol-3-yl)-benzonitrile except Degussa type E101 NE/W 10% Palladium on activated carbon can be used instead of platinum (II) oxide in Method E. LRMS (API ES+)=277.0 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07932284B2 |
| 出典データセット | uspto-grants-2011_04 |
| ORD ID | ord-06449a27ab5444758edff0c311d6740c |
| 出典メモ | uspto-grants-2011_04 |