Potassium Hydroxide → 4-(1-cyclopentyl-6-nitro-1H-indol-3-yl)-benzonitrile

HRID 2079898

反応式

HRID 2079898 の反応式
[OH-].[K+].[N+:3]([C:6]1[CH:14]=[C:13]2[C:9]([C:10]([C:15]3[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][CH:16]=3)=[CH:11][NH:12]2)=[CH:8][CH:7]=1)([O-:5])=[O:4].S(C1C=CC(C)=CC=1)(O[CH:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1)(=O)=O>CS(C)=O>[CH:27]1([N:12]2[C:13]3[C:9](=[CH:8][CH:7]=[C:6]([N+:3]([O-:5])=[O:4])[CH:14]=3)[C:10]([C:15]3[CH:16]=[CH:17][C:18]([C:19]#[N:20])=[CH:21][CH:22]=3)=[CH:11]2)[CH2:31][CH2:30][CH2:29][CH2:28]1

参加物

5

反応物 3

HCID 14797Potassium Hydroxide2 回HCID 317685Cyclopentyl 4-methylbenzene-1-sulfonate2 回HCID 574421974-(6-nitro-1H-indol-3-yl)-benzonitrile

生成物 1

HCID 574422444-(1-cyclopentyl-6-nitro-1H-indol-3-yl)-benzonitrile収率 58%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒2 回

実験手順

Method M Add KOH pellets (200 mg, 3.42 mmol) to a solution of 4-(6-nitro-1H-indol-3-yl)-benzonitrile, 9, (150 mg, 0.57 mmol) in DMSO (10 mL). After the KOH pellets dissolve, add cyclopenyl tosylate (210 mg, 0.85 mmol) in DMSO (3 mL). Allow the reaction mixture to stir overnight at ambient temperature. Add additional cyclopentyl tosylate (210 mg, 0.85) and allow the reaction mixture to stir for another 6 h. Add still more cyclopentyl tosylate (210 mg, 0.85 mmol) and allow the reaction mixture to stir overnight at ambient temperature. Quench the resulting reaction mixture with 5N HCl/ice. Extract the quenched reaction mixture with EtOAc. Wash the EtOAc extracts with brine. Dry the organic layer over MgSO4, filter, and remove the solvent from the filtrate to provide a solid. Purify by silica gel column chromatography (0-100% EtOAc/hexanes gradient) and collect the fractions and remove the solvent to afford 110 mg (58%) of the title compound. LRMS (API ES+)=332.2 (M+H).

後処理

  1. stirringto stir for another 6 h
  2. stirringto stir overnight at ambient temperature
  3. customQuench
  4. customthe resulting reaction mixture with 5N HCl/ice
  5. extractionExtract
  6. customthe quenched reaction mixture with EtOAc
  7. washWash the EtOAc
  8. dry with materialDry the organic layer over MgSO4
  9. filtrationfilter
  10. customremove the solvent from the filtrate
  11. customto provide a solid
  12. customPurify by silica gel column chromatography (0-100% EtOAc/hexanes gradient)
  13. customcollect the fractions
  14. customremove the solvent

出典と根拠

ORDレコード
ord-59925e9d0a3643939c0cd70ec81fdb67
出典データセット
uspto-grants-2011_04
特許番号
US07932284B2

関連ノート

読み込み中…