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Sodium borohydride → (+/-)[2-Ethyl-1-phenyl-2-(1-pyrrolidinyl)butyl]amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | [2-Methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]amine | HCID 25158607 | — |
| 反応物 | 2-Ethyl-2-(1-pyrrolidinyl)butanenitrile | HCID 43802763 | — |
| 反応物 | HCID 178506676 | HCID 178506676 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Butyl ether | HCID 8909 | — |
| 生成物 | (+/-)[2-Ethyl-1-phenyl-2-(1-pyrrolidinyl)butyl]amine | HCID 59347778 | 88% |
反応手順
The title compound (11.5 g, 88%) was prepared from 2-ethyl-2-(1-pyrrolidinyl)butanenitrile D17 (8.8 g, 0.053 mol) and phenyllithium in dibutylether (59 ml of a 1.8M solution; 0.106 mol) in THF (350 ml), followed by reaction with sodium borohydride (3.9 g, 0.103 mol) in methanol (300 ml) in a similar manner to that described in D5. 1H NMR (CDCl3) δ: 0.75 (3H, t), 0.95 (3H, t, J=7.6 Hz), 1.50-1.90 (10H, m), 2.70-2.95 (4H, m), 4.01 (1H, s), 7.19-7.41 (5H, m).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745642B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-b04688027dfa4aa1b88601dc5145dfa7 |
| 出典メモ | uspto-grants-2010_06 |