関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 4-Chloroaniline | HCID 7812 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | 3-Phenylprop-2-enoyl chloride | HCID 66023 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-(4-Chlorophenyl)-3-phenylacrylamide | HCID 303259 | — |
反応手順
To a mixture of 4-chloroaniline (16.2 g), toluene (120 ml), and pyridine (11 ml) at 0° C., cinnamoyl chloride (20.0 g) in 120 ml of toluene was added dropwise. After stirring 15 minutes at 0° C. the reaction mixture was poured into a mixture of ethyl acetate: water (250 ml:250 ml). The organic layer was separated and extracted with 5% aqueous HCl (3×250 ml), water (1×250 ml), 5% aqueous sodium bicarbonate (3×250 ml), dried over anhydrous sodium sulfate and yielding the amide as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05728694 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-06bfd03f154d4600bce4486454c4cfc1 |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
