Malononitrile → HCID 23130524、化合物
反応式
C(OC(=O)[NH:7][C:8]1[CH:12]=[CH:11][S:10][C:9]=1[CH:13]=O)(C)(C)C.[C:16](#[N:20])[CH2:17][C:18]#[N:19]>C(O)C.N1CCCCC1>[NH2:19][C:18]1[N:7]=[C:8]2[CH:12]=[CH:11][S:10][C:9]2=[CH:13][C:17]=1[C:16]#[N:20]参加物
5
実験手順
(2-Formyl-thiophen-3-yl)-carbamic acid tert-butyl ester described in Preparation Example U-2 (500 mg, 2.20 mmol) and malononitrile (153 mg, 2.31 mmol) were dissolved in a solution of ethanol (10 mL) to which piperidine (catalytic amount) had been added, and the mixture was stirred for 1 hour under reflux. The reaction mixture was cooled to room temperature, the precipitated solid was filtered, and title compound (215 mg, 1.23 mmol, 56%) was obtained as a white solid.
後処理
- additionhad been added
- temperatureunder reflux
- filtrationthe precipitated solid was filtered
出典と根拠
- ORDレコード
- ord-cdd6237243484aa58cafe097028703eb
- 出典データセット
- uspto-grants-2011_04
- 特許番号
- US07932272B2
反応ノート
読み込み中…