HCID 22118244、化合物 → HCID 23130679、化合物

HRID 2080055ノート

反応式

HRID 2080055 の反応式
[O:1]([C:8]1[N:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[C].[Pd]>[O:1]([C:8]1[N:13]=[C:12]([CH2:14][NH2:15])[CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 22118244HCID 22118244、化合物

生成物 1

HCID 23130679HCID 23130679、化合物収率 64%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

10% Palladium-carbon (50 mg) was added to a solution of the resulting 6-phenoxy-pyridine-2-carbonitrile (100 mg, 0.51 mmol) in methanol (5.0 mL), the mixture was stirred at room temperature for 24 hours under hydrogen atmosphere (1 atm). The catalyst was removed by filtration, and the filtrate was concentrated to obtain the title compound (65 mg, 64%) as a colorless oil.

後処理

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-6cf3f745fbea453dacd81900205c47de
出典データセット
uspto-grants-2011_04
特許番号
US07932272B2

反応ノート

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