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5-Benzylfuran-2-carbaldehyde → 5-(Phenylmethyl)-2-furanmethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Benzylfuran-2-carbaldehyde | HCID 12418537 | — |
| 反応物 | Ammonia methanol | HCID 21705897 | — |
| 触媒 | Nickel | HCID 935 | — |
| 生成物 | 5-(Phenylmethyl)-2-furanmethanamine | HCID 23130620 | 65.8% |
反応手順
7N Ammonia/methanol(40 mL) and Raney nickel(3 g) were added to 5-benzyl-furan-2-carbaldehyde described in Preparation Example 39 (2.5 g, 13 mmol), and the solution was stirred for 22 hours under hydrogen atmosphere at room temperature. After removing the catalyst by filtering through Celite pad, the solvent was evaporated in vacuo and C-(5-benzyl-furan-2-yl)methylamine (1.6 g, 8.6 mmol, 65.8%) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07932272B2 |
| 出典データセット | uspto-grants-2011_04 |
| ORD ID | ord-fa9049e0f9524da9bf4ee48ab4ee6885 |
| 出典メモ | uspto-grants-2011_04 |