Sucralose 6-acetate → (2R,3S,4R,5R,6S)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol

HRID 2080536

反応式

HRID 2080536 の反応式
CC([O:4][CH2:5][C@H:6]1[O:11][C@H:10]([O:12][C@:13]2([CH2:22][Cl:23])[O:17][C@H:16]([CH2:18][Cl:19])[C@@H:15]([OH:20])[C@@H:14]2[OH:21])[C@H:9]([OH:24])[C@@H:8]([OH:25])[C@H:7]1[Cl:26])=O.C[O-].[Na+]>CO>[CH2:5]([OH:4])[C@@H:6]1[O:11][C@H:10]([O:12][C@:13]2([CH2:22][Cl:23])[O:17][C@H:16]([CH2:18][Cl:19])[C@@H:15]([OH:20])[C@@H:14]2[OH:21])[C@@H:9]([OH:24])[C@@H:8]([OH:25])[C@H:7]1[Cl:26]

参加物

4

反応物 2

HCID 10094747Sucralose 6-acetateHCID 10942334Sodium Methoxide

生成物 1

HCID 70683051(2R,3S,4R,5R,6S)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol収率 66.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 15.8g of sucralose-6-acetate and 120g of methanol was added by 0.15g of sodium methoxide. The reaction mixture was stirred at 30° for 4 hours. Then, the reaction mixture was neutralized to pH7, filtered and then the filtrate was decolored with activated carbon and concentrated under vacuum condition to afford the crude sucralose. The crude was recrystallized from water to afford 9.5g of pure sucralose with over 99% purity.

後処理

  1. filtrationfiltered
  2. concentrationconcentrated under vacuum condition
  3. customto afford the crude sucralose
  4. customThe crude was recrystallized from water

出典と根拠

ORDレコード
ord-bd74fed623ec4bf9b24d0babebfddd4e
出典データセット
uspto-grants-2011_04
特許番号
US07932380B2

関連ノート

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