Dimethylformamide → Methyl 2-[4-(ethylsulfonyl)phenoxy]-5-nitro-4-[(2-pyridinylcarbonyl)amino]benzoate

HRID 2080666ノート

反応式

HRID 2080666 の反応式
C(=O)([O-])[O-].[K+].[K+].CN(C)C=O.F[C:13]1[CH:22]=[C:21]([NH:23][C:24]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=2)=[O:25])[C:20]([N+:32]([O-:34])=[O:33])=[CH:19][C:14]=1[C:15]([O:17][CH3:18])=[O:16].[CH2:35]([S:37]([C:40]1[CH:45]=[CH:44][C:43]([OH:46])=[CH:42][CH:41]=1)(=[O:39])=[O:38])[CH3:36]>O>[CH2:35]([S:37]([C:40]1[CH:45]=[CH:44][C:43]([O:46][C:13]2[CH:22]=[C:21]([NH:23][C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=3)=[O:25])[C:20]([N+:32]([O-:34])=[O:33])=[CH:19][C:14]=2[C:15]([O:17][CH3:18])=[O:16])=[CH:42][CH:41]=1)(=[O:39])=[O:38])[CH3:36]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 202362274-(Ethanesulfonyl)phenolHCID 57433540HCID 57433540、化合物

生成物 1

HCID 57433541Methyl 2-[4-(ethylsulfonyl)phenoxy]-5-nitro-4-[(2-pyridinylcarbonyl)amino]benzoate収率 82.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

3.5 g of potassium carbonate was added to a dimethylformamide (110 ml) solution of 6 g of methyl 2-fluoro-5-nitro-4-[(2-pyridinylcarbonyl)amino]benzoate and 3.48 g of 4-(ethylsulfonyl)phenol obtained in Reference Example 2, and stirred under heat at 80° C. for 30 minutes. The reaction liquid was restored to room temperature, poured into 300 ml of water, and the formed solid was taken out through filtration. This was dried under reduced pressure to obtain 7.46 g of the entitled compound as a yellow solid.

後処理

  1. customobtained in Reference Example 2
  2. customThe reaction liquid
  3. customwas restored to room temperature
  4. filtrationthe formed solid was taken out through filtration
  5. customThis was dried under reduced pressure

出典と根拠

ORDレコード
ord-e12567b778ec454bb495e6be41f75441
出典データセット
uspto-grants-2011_04
特許番号
US07932394B2

反応ノート

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