Methyl 5-[4-(ethylsulfonyl)phenoxy]-2-nitrobenzoate → Methyl 2-amino-5-[4-(ethylsulfonyl)phenoxy]benzoate

HRID 2080669ノート

反応式

HRID 2080669 の反応式
[CH2:1]([S:3]([C:6]1[CH:25]=[CH:24][C:9]([O:10][C:11]2[CH:12]=[CH:13][C:14]([N+:21]([O-])=O)=[C:15]([CH:20]=2)[C:16]([O:18][CH3:19])=[O:17])=[CH:8][CH:7]=1)(=[O:5])=[O:4])[CH3:2].[H][H]>[Ni].CO>[NH2:21][C:14]1[CH:13]=[CH:12][C:11]([O:10][C:9]2[CH:24]=[CH:25][C:6]([S:3]([CH2:1][CH3:2])(=[O:5])=[O:4])=[CH:7][CH:8]=2)=[CH:20][C:15]=1[C:16]([O:18][CH3:19])=[O:17]

参加物

5

反応物 2

HCID 57433573Methyl 5-[4-(ethylsulfonyl)phenoxy]-2-nitrobenzoateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 57433574Methyl 2-amino-5-[4-(ethylsulfonyl)phenoxy]benzoate収率 41.4%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

0.7 g of Raney nickel was added to a methanol (150 ml) solution of 6.98 g of methyl 5-[4-(ethylsulfonyl)phenoxy]-2-nitrobenzoate, and stirred overnight in a hydrogen atmosphere. The catalyst was removed through filtration, the solvent was evaporated away under reduced pressure, and the residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=2/1 to 1/1) to obtain 2.65 g of the entitled compound as a colorless oil.

後処理

  1. customThe catalyst was removed through filtration
  2. customthe solvent was evaporated away under reduced pressure
  3. customthe residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=2/1 to 1/1)

出典と根拠

ORDレコード
ord-105941c73559491bac8c38c208e349f1
出典データセット
uspto-grants-2011_04
特許番号
US07932394B2

反応ノート

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