2-[2-(4-Dipropylaminobutyl)-1-methoxymethoxy-indan-5-ylmethyl]-isoindole-1,3-dione → 2-[2-(4-dipropylamino-butyl)-3H-inden-5-ylmethyl]-isoindol

HRID 2080739ノート

反応式

HRID 2080739 の反応式
[CH2:1]([N:4]([CH2:34][CH2:35][CH3:36])[CH2:5][CH2:6][CH2:7][CH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH2:18][N:19]3[C:27](=O)[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[C:20]3=O)[CH:15]=2)[CH:10]1OCOC)[CH2:2][CH3:3]>O1CCOCC1>[CH2:34]([N:4]([CH2:1][CH2:2][CH3:3])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH2:18][N:19]3[CH:27]=[C:26]4[C:21]([CH:22]=[CH:23][CH:24]=[CH:25]4)=[CH:20]3)[CH:15]=2)[CH:10]=1)[CH2:35][CH3:36]

参加物

3

反応物 1

HCID 231555482-[2-(4-Dipropylaminobutyl)-1-methoxymethoxy-indan-5-ylmethyl]-isoindole-1,3-dione

生成物 1

HCID 866149102-[2-(4-dipropylamino-butyl)-3H-inden-5-ylmethyl]-isoindol収率 107.5%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

The compound (113.0 mg) obtained in Example 11-11 was dissolved in dioxane (2.2 ml) and the whole was stirred at room temperature for 24 hours. The reaction solution was concentrated under reduced pressure. The residue was dissolved in chloroform and washed with a saturated aqueous sodium hydrogen carbonate solution and then with a saturated saline solution. The resultant was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (98.8 mg) as a yellow oily substance.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. dissolutionThe residue was dissolved in chloroform
  3. washwashed with a saturated aqueous sodium hydrogen carbonate solution
  4. dry with materialThe resultant was dried with anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was purified through silica gel column chromatography (chloroform/methanol)

出典と根拠

ORDレコード
ord-f679ddba13f148f0859a4e35168388f2
出典データセット
uspto-grants-2011_04
特許番号
US07932281B2

反応ノート

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