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Hydrogen Cyanide → 1-[Methyl(phenylmethyl)amino]cyclopentanecarbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Cyanide | HCID 768 | — |
| 反応物 | N-Methylbenzylamine | HCID 7669 | — |
| 反応物 | Cyclopentanone | HCID 8452 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | 1-(Dimethylamino)cyclopentanecarbonitrile | HCID 10773049 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-[Methyl(phenylmethyl)amino]cyclopentanecarbonitrile | HCID 21581544 | 84% |
反応手順
The title compound (15 g; 84%) was prepared from N-methylbenzylamine (10.08 g; 83 mmol), cyclopentanone (7 g; 83 mmol) and potassium cyanide (5.41 g; 83 mmol) in water (45 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 1.90 (6H, m), 2.20 (3H, s), 2.3 (2H, m), 3.62 (2H, s), 7.25 (1H, m), 7.32 (4H, m); Mass Spectrum (Electrospray LC/MS): Found 188 (MH+−HCN). C14H18N2 requires 214. Ret. time 1.21 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745642B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-3c8c8663029b447da3e44042b0133a60 |
| 出典メモ | uspto-grants-2010_06 |