Hydrochloric Acid → HCID 11670688、化合物

HRID 2080855ノート

反応式

HRID 2080855 の反応式
C[O:2][C:3](=[O:38])[CH2:4][N:5]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][N:25]([CH2:32][C:33]2[NH:34][CH:35]=[CH:36][N:37]=2)[CH2:26][C:27]2[NH:28][CH:29]=[CH:30][N:31]=2)=[CH:20][CH:19]=1)[CH2:6][CH2:7][CH2:8][CH2:9][N:10]([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13].Cl>O>[NH:28]1[CH:29]=[CH:30][N:31]=[C:27]1[CH2:26][N:25]([CH2:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][N:5]([CH2:4][C:3]([OH:38])=[O:2])[CH2:6][CH2:7][CH2:8][CH2:9][N:10]([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13])=[CH:19][CH:20]=1)[CH2:32][C:33]1[NH:37][CH:36]=[CH:35][N:34]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 11533761HCID 11533761、化合物

生成物 1

HCID 11670688HCID 11670688、化合物収率 74%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The compound (533.4 mg) obtained in Example 68-1 was dissolved in water (0.5 ml) and added with concentrated hydrochloric acid (2.5 ml). The whole was refluxed under heating for 30 minutes. After completion of the reaction, the solvent was distilled off, thereby obtaining a hydrochloride (384.1 mg) of the subject compound as a white solid.

後処理

  1. temperatureThe whole was refluxed
  2. temperatureunder heating for 30 minutes
  3. customAfter completion of the reaction
  4. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-4da547024b0c4f808c8a0afcbe4ccb63
出典データセット
uspto-grants-2011_04
特許番号
US07932281B2

反応ノート

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