Diethylamine → HCID 86614920、化合物

HRID 2080894ノート

反応式

HRID 2080894 の反応式
[CH2:1]([O:3][C:4](=[O:35])[C@H:5]([NH:17]C(OCC1C2C=CC=CC=2C2C1=CC=CC=2)=O)[CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH3:2].C(NCC)C>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:35])[C@H:5]([NH2:17])[CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][C:13]([CH3:15])([CH3:14])[CH3:16])=[O:11])[CH3:2]

参加物

4

反応物 2

HCID 8021DiethylamineHCID 67103783HCID 67103783、化合物

生成物 1

HCID 86614920HCID 86614920、化合物収率 114.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The compound (1.9846 g) obtained in Example 96-1 was dissolved in DMF (19 ml) and added with diethylamine (14 ml) and the whole was stirred at room temperature for 30 minutes. After completion of the reaction, the solvent was distilled off. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (1.2212 g) as a colorless oily substance.

後処理

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off
  3. customThe residue was purified through silica gel column chromatography (chloroform/methanol)

出典と根拠

ORDレコード
ord-ac75322babd2480d9dd16a284b29588a
出典データセット
uspto-grants-2011_04
特許番号
US07932281B2

反応ノート

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