Trimethyl orthoformate → N-(4-{[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzylidene)-N',N'-dipropyl-butane-1,4-diamine

HRID 2080896ノート

反応式

HRID 2080896 の反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][N:7]([CH2:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=1)[CH2:8][C:9]1[N:10]([CH3:14])[CH:11]=[CH:12][N:13]=1.[CH2:24]([N:27]([CH2:33][CH2:34][CH3:35])[CH2:28][CH2:29][CH2:30][CH2:31][NH2:32])[CH2:25][CH3:26].C(OC)(OC)OC>CO>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][N:7]([CH2:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[N:32][CH2:31][CH2:30][CH2:29][CH2:28][N:27]([CH2:33][CH2:34][CH3:35])[CH2:24][CH2:25][CH3:26])=[CH:18][CH:17]=1)[CH2:8][C:9]1[N:10]([CH3:14])[CH:11]=[CH:12][N:13]=1

参加物

5

反応物 3

HCID 9005Trimethyl orthoformateHCID 7138396N,N-dipropylbutane-1,4-diamineHCID 866149184-[[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl]-benzaldehyde

生成物 1

HCID 67103803N-(4-{[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzylidene)-N',N'-dipropyl-butane-1,4-diamine収率 103.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The compound (210 mg) obtained in Example 84-5 was dissolved in anhydrous methanol (6.3 ml) and added with the compound (117 mg) obtained in Example 1-2. The solution was added with trimethyl orthoformate (297 μl) and the whole was stirred at room temperature for 6.5 hours. After completion of the reaction, the solvent was distilled off, thereby obtaining the subject compound (325 mg) as a brown oily substance.

後処理

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-e7731e41b0d8455ba2f8e92f61c3a335
出典データセット
uspto-grants-2011_04
特許番号
US07932281B2

反応ノート

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