3-(Dihydroxyboranyl)-5-nitrobenzoic acid → 3-Amino-5-carboxybenzeneboronic acid

HRID 2081160ノート

反応式

HRID 2081160 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([B:13]([OH:15])[OH:14])[CH:7]=[C:8]([C:10]([OH:12])=[O:11])[CH:9]=1)([O-])=O>C(O)C.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([B:13]([OH:15])[OH:14])[CH:7]=[C:8]([C:10]([OH:12])=[O:11])[CH:9]=1

参加物

4

反応物 1

HCID 27733153-(Dihydroxyboranyl)-5-nitrobenzoic acid

生成物 1

HCID 27377953-Amino-5-carboxybenzeneboronic acid

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

A solution of 3-nitro-5-carboxyphenylboronic acid (3.3 g, 0.016 mol) in absolute ethanol (25 ml) was hydrogenated in the presence of Raney Nickel (1 g) at 50 lbs per square inch for 4 hours in a Parr shaker. The catalyst was removed by filtration and the solvent was removed on a rotary evaporator. The solid obtained was recrystallized from water. M.P. 210°-12° C.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe solvent was removed on a rotary evaporator
  3. customThe solid obtained
  4. customwas recrystallized from water

出典と根拠

ORDレコード
ord-a056b2747fc642c888a1c555e1156aee
出典データセット
uspto-grants-1993_02
特許番号
US05183653

反応ノート

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