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Benzaldehyde → N-benzylidene-D-phenylalanine methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Triethylamine hydrochloride | HCID 11130 | — |
| 反応物 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 反応物 | D-Phenylalanine | HCID 71567 | — |
| 反応物 | D-phenylalanine hydrochloride | HCID 13000988 | — |
| 生成物 | N-benzylidene-D-phenylalanine methyl ester | HCID 24807472 | — |
反応手順
To a suspension of 1.0 eq D-phenylalanine HCl (1.6 g, 7.4 mmol) was added 1.0 eq triethylamine to dissolve the D-phenylalanine. To this solution was added 1 equiv. of MgSO4 followed by the addition of 1.0 eq benzaldehyde, the reaction was stirred overnight at room temperature under N2 atmosphere. The reaction mixture was stripped of solvent and pumped on the residue contained a good deal of triethylamine hydrochloride which was removed by dissolving the product in THF and filtering out the TEA.HCl. The crude benzylidene looked fine by NMR and was all taken on in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05183810 |
| 出典データセット | uspto-grants-1993_02 |
| ORD ID | ord-cd29c541c53347718afc357569e07a57 |
| 出典メモ | uspto-grants-1993_02 |