2-Fluoroaniline → 4-[(2-Fluorophenyl)amino]-5,6-dihydro-2(1H)-pyridinone
反応式
[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[O:9]=[C:10]1[CH2:15][C:14](=O)[CH2:13][CH2:12][NH:11]1>>[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:14]1[CH2:13][CH2:12][NH:11][C:10](=[O:9])[CH:15]=1参加物
3
実験手順
A mixture of 2-fluoroaniline (0.98 g) and 2,4-dioxopiperidine (1.0 g) was heated at 120° for 2 h. The cooled mixture was triturated with dry ether (5×40 ml) and the solvent was decanted to leave the title compound (1.495 g), m.p. 98°-100°.
後処理
- temperaturewas heated at 120° for 2 h
- customThe cooled mixture was triturated with dry ether (5×40 ml)
- customthe solvent was decanted
出典と根拠
- ORDレコード
- ord-7ba40ddaf9564399b95a53c6c51609e1
- 出典データセット
- uspto-grants-1993_02
- 特許番号
- US05183820
反応ノート
読み込み中…