2,6-Dibromoaniline → 4-[(2,6-Dibromophenyl)amino]-5,6-dihydro-2(1H)-pyridinone

HRID 2081194ノート

反応式

HRID 2081194 の反応式
[Br:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([Br:9])[C:3]=1[NH2:4].[O:10]=[C:11]1[CH2:16][C:15](=O)[CH2:14][CH2:13][NH:12]1>>[Br:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([Br:9])[C:3]=1[NH:4][C:15]1[CH2:14][CH2:13][NH:12][C:11](=[O:10])[CH:16]=1

参加物

3

反応物 2

HCID 690982,6-DibromoanilineHCID 108878632,4-Piperidinedione

生成物 1

HCID 157124964-[(2,6-Dibromophenyl)amino]-5,6-dihydro-2(1H)-pyridinone収率 29.7%

実験手順

A mixture of 2,6-dibromoaniline (4.4 g) and 2,4-dioxopiperidine (2.0 g) was heated at 120° for 2.5 h. The mixture was then cooled (0°) and triturated with ether 9100 ml) to give a solid which was purified by FCC eluting with System A (100:8:1) to give the title compound (1.8 g), m.p. 240°-243°.

後処理

  1. temperaturewas heated at 120° for 2.5 h
  2. temperatureThe mixture was then cooled (0°)
  3. customtriturated with ether 9100 ml)
  4. customto give a solid which
  5. customwas purified by FCC
  6. washeluting with System A (100:8:1)

出典と根拠

ORDレコード
ord-ac2dbf2e68924409a88120ab5a14fdc4
出典データセット
uspto-grants-1993_02
特許番号
US05183820

反応ノート

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