HCID 3265055、化合物 → 8-Fluoro-1,2,3,9-tetrahydro-4H-carbazol-4-one
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[CH2:14][CH2:13][CH2:12][C:11](=[O:15])[CH:10]=1>CN(C=O)C.C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[NH:8][C:9]1[CH2:14][CH2:13][CH2:12][C:11](=[O:15])[C:10]2=1参加物
5
実験手順
3-[(2-Fluorophenyl)amino]-2-cylcohexen-1-one (14.8 g), palladium (II) acetate (1 g), and copper (II) acetate (29.5 g) were heated together in DMF (10 ml) under nitrogen at 140° for 2 h. The solvent was removed in vacuo, and the residue was purified by FCC eluting with ether to give the title compound (10.1 g), m.p. 222°-224°.
後処理
- customThe solvent was removed in vacuo
- customthe residue was purified by FCC
- washeluting with ether
出典と根拠
- ORDレコード
- ord-2ba354f326464fce8bb2d64a6469a19f
- 出典データセット
- uspto-grants-1993_02
- 特許番号
- US05183820
反応ノート
読み込み中…