Hydrochloric Acid → 3-Acetyl-5-Ethyldihydro-2(3H)-Furanone

HRID 2081276ノート

反応式

HRID 2081276 の反応式
Cl.O1C=C[CH2:4][C:3]1=O.[C:8]([O:14][CH2:15][CH3:16])(=[O:13])[CH2:9][C:10]([CH3:12])=[O:11]>>[C:10]([CH:9]1[CH2:16][CH:15]([CH2:3][CH3:4])[O:14][C:8]1=[O:13])(=[O:11])[CH3:12]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 8868Ethyl AcetoacetateHCID 1407652(3H)-Furanone

生成物 1

HCID 110518973-Acetyl-5-Ethyldihydro-2(3H)-Furanone

実験手順

The mixture was allowed to stand overnight and was transferred to a separatory funnel and acidified with 125 ml concentrated hydrochloric acid. The organic layer was separated and the water layer extracted three times with 50 ml diethyl ether. The extracts were combined with the organic layer, dried through sodium sulfate, and the diethyl ether was removed by means of a Rotovap. 182 Grams of product were obtained which when analyzed by GC indicated 83.6% lactone and 7.8% ethyl acetoacetate.

後処理

  1. customwas transferred to a separatory funnel
  2. customThe organic layer was separated
  3. extractionthe water layer extracted three times with 50 ml diethyl ether
  4. dry with materialdried through sodium sulfate
  5. customthe diethyl ether was removed by means of a Rotovap
  6. custom182 Grams of product were obtained which when

出典と根拠

ORDレコード
ord-1152ca29cf0443d6a45cba7eb31966cb
出典データセット
uspto-grants-1993_02
特許番号
US05183908

反応ノート

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