2-Bromophenol → 4-(2-Bromophenoxy)butyric acid ethyl ester

HRID 2081309ノート

反応式

HRID 2081309 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[CH2:9]([O:11][C:12](=[O:17])[CH2:13][CH2:14][CH2:15]Br)[CH3:10].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O>[CH2:9]([O:11][C:12](=[O:17])[CH2:13][CH2:14][CH2:15][O:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Br:1])[CH3:10]

参加物

5

反応物 3

HCID 72442-BromophenolHCID 10796Cesium carbonateHCID 76300Ethyl 4-bromobutyrate

生成物 1

HCID 150701144-(2-Bromophenoxy)butyric acid ethyl ester収率 85.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

8.65 g of bromophenol and 8.75 g of 4-bromobutyric acid ethyl ester are dissolved in 120 ml of dimethylformamide, mixed with 32.6 g of cesium carbonate and stirred for 2 days at room temperature. The reaction mixture is filtered, the solvent is distilled off in a vacuum and the residue is distilled in a bulb tube at 180° C./0.4 mbar. 11 g of 4-(2-bromophenoxy)butyric acid ethyl ester is obtained as a colorless oil.

後処理

  1. filtrationThe reaction mixture is filtered
  2. distillationthe solvent is distilled off in a vacuum
  3. distillationthe residue is distilled in a bulb tube at 180° C./0.4 mbar

出典と根拠

ORDレコード
ord-502ccf6aea974a858717eeda5255c69c
出典データセット
uspto-grants-1993_02
特許番号
US05183925

反応ノート

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