Methanol → 4-(2-Bromophenoxy)-butyric acid methyl ester

HRID 2081313ノート

反応式

HRID 2081313 の反応式
[Br:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9].[CH3:15]O>>[CH3:15][O:9][C:8](=[O:10])[CH2:7][CH2:6][CH2:5][O:4][C:3]1[CH:11]=[CH:12][CH:13]=[CH:14][C:2]=1[Br:1]

参加物

3

反応物 2

HCID 887MethanolHCID 150701174-(2-Bromophenoxy)butanoic acid

生成物 1

HCID 150701264-(2-Bromophenoxy)-butyric acid methyl ester

実験手順

A solution of 1.4 g of 4-(2-bromophenoxy)-butyric acid in 22 ml of methanol is mixed with 1 g of Amberlyst 15 and stirred for 5 hours at room temperature. Then, it is filtered from the Amberlyst 15, the filtrate concentrated by evaporation, the residue is taken up in diethyl ether, washed with dilute sodium carbonate solution, dried (Na2SO4) and concentrated by evaporation. 1.5 g of 4-(2-bromophenoxy)-butyric acid methyl ester is obtained as a colorless oil.

後処理

  1. filtrationThen, it is filtered from the Amberlyst 15
  2. concentrationthe filtrate concentrated by evaporation
  3. washwashed with dilute sodium carbonate solution
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-72a4b8b5e6d044a1b9b7578c2b60f9bb
出典データセット
uspto-grants-1993_02
特許番号
US05183925

反応ノート

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