Hydrogen Peroxide → 2-Benzyl-1-oxo-1lambda~5~-pyridine
反応式
[CH2:1]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:14]O>C(O)(=O)C>[CH2:1]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N+:9]=1[O-:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
A solution of 2-benzylpyridine (10.0 g, 0.059 moles) and hydrogen peroxide (33% w/v, 4.02 g, 12.2 ml, 0.118 moles) in glacial acetic acid (40 ml) was heated at 60° C. for 17 hours. The reaction mixture was cooled to room temperature, the acetic acid evaporated under reduced pressure and the residue dissolved in chloroform. After neutralisation with potassium carbonate (20 g) the chloroform was removed to give 2-benzylpyridine-N-oxide (10.86 g, 99%) as a viscous oil which crystallised on standing.
後処理
- customthe acetic acid evaporated under reduced pressure
- dissolutionthe residue dissolved in chloroform
- customAfter neutralisation with potassium carbonate (20 g) the chloroform was removed
出典と根拠
- ORDレコード
- ord-2fc156addcf546b79a1475884229092c
- 出典データセット
- uspto-grants-1993_02
- 特許番号
- US05185339
反応ノート
読み込み中…