Sodium Methoxide → Methyl 6-benzyl-2-picoline imidate
反応式
[CH2:1]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]#[N:15])[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:16][O-:17].[Na+]>CO>[CH2:1]([C:8]1[N:9]=[C:10]([C:14](=[NH:15])[O:17][CH3:16])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
反応条件
- 温度
- 20 °C
実験手順
2-Benzyl-6-cyanopyridine (0.84 g, 0.0043 moles) was added to a solution of sodium methoxide in methanol [prepared by dissolving sodium metal (0.11 g, 0.0047 gram atoms) in methanol (10 ml)] and the mixture stirred at 20° C. for 5 hours. The methanol was evaporated, the residue taken up in chloroform and the precipitate filtered off through a silica bed. Removal of the solvent from the filtrate gave methyl 6-benzyl-2-picoline imidate (0.81 g, 84%) which was used in the next stage without further purification.