Hydrogen Peroxide → HCID 19780238、化合物

HRID 2081586ノート

反応式

HRID 2081586 の反応式
[Cl:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1.[OH:15]O>C(O)(=O)C>[Cl:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N+:6]=1[O-:15]

参加物

4

反応物 2

HCID 784Hydrogen PeroxideHCID 124351852-[(2-Chlorophenyl)methyl]pyridine

生成物 1

HCID 19780238HCID 19780238、化合物収率 100%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 2-(o-chlorobenzyl)pyridine (32 g, 0.16 moles) and hydrogen peroxide (30% w/v, 10.7 g, 36.0 ml, 0.31 moles) in glacial acetic acid (100 ml) was heated at 75° C. for 17 hours. The reaction mixture was cooled to room temperature, the acetic acid evaporated under reduced pressure and the residue dissolved in chloroform. After neutralisation with potassium carbonate (30 g) the chloroform was removed to give 2-(o-chlorobenzyl)pyridine-N-oxide (34.4 g, 100%) as a viscous oil.

後処理

  1. customthe acetic acid evaporated under reduced pressure
  2. dissolutionthe residue dissolved in chloroform
  3. customAfter neutralisation with potassium carbonate (30 g) the chloroform was removed

出典と根拠

ORDレコード
ord-26b07bd79075432c8b440f9728a0dbde
出典データセット
uspto-grants-1993_02
特許番号
US05185339

反応ノート

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