Bromine → (2E)-2-[2-(4-bromophenoxy)phenyl]-2-methoxyimino-N-methylacetamide

HRID 2081628

反応式

HRID 2081628 の反応式
[CH3:1][NH:2][C:3](=[O:21])/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[N:5]/[O:6][CH3:7].[Br:22]Br>C(Cl)(Cl)(Cl)Cl>[CH3:1][NH:2][C:3](=[O:21])/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:16]=[CH:17][C:18]([Br:22])=[CH:19][CH:20]=1)=[N:5]/[O:6][CH3:7]

参加物

4

反応物 2

HCID 24408BromineHCID 5483872(2E)-2-methoxyimino-N-methyl-2-(2-phenoxyphenyl)acetamide

生成物 1

HCID 19429892(2E)-2-[2-(4-bromophenoxy)phenyl]-2-methoxyimino-N-methylacetamide

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒2 回

実験手順

A solution of (E)-N-methyl-2-(2-phenoxyphenyl)-2-methoxyiminoacetamide (500 mg) in carbon tetrachloride (3 ml) was cooled to 0° C., and bromine in carbon tetrachloride (1.27 mmol) was dropwise added thereto. The resulant mixture was stirred at the same temperature for 1 hour, washed with a saturated aqueous sodium hydrogencarbonate solution and extracted with dichloroethane. The solvent was dried and evaporated, and the residue was subjected to HPLC with a mixture of hexane and ethyl acetate to give 200 mg of the objective compound.

後処理

  1. washwashed with a saturated aqueous sodium hydrogencarbonate solution
  2. extractionextracted with dichloroethane
  3. customThe solvent was dried
  4. customevaporated
  5. additionthe residue was subjected to HPLC with a mixture of hexane and ethyl acetate

出典と根拠

ORDレコード
ord-1d7932d0b72a437cba7d66dd46abec0d
出典データセット
uspto-grants-1993_02
特許番号
US05185342

関連ノート

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