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4-Methoxybenzyl alcohol → p-Methoxybenzyl acrylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methoxybenzyl alcohol | HCID 7738 | — |
| 反応物 | (E)-3-[2-n-Butyl-1-[(2-chlorophenyl)methyl]-4-hydroxymethyl-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic acid | HCID 70041240 | — |
| 生成物 | p-Methoxybenzyl acrylate | HCID 346146 | — |
反応手順
(E)-3-[2-n-Butyl-1-[(2-chlorophenyl)methyl]-4-hydroxymethyl-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic acid, prepared as in Example 19, is esterified with 4-methoxy-benzyl alcohol to give the p-methoxybenzyl propenoate. The 4-hydroxymethyl group in acetone is oxidized using an acidic aqueous solution containing chromic acid (Jones' reagent) and the ester is hydrolyzed using 10% sodium hydroxide to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05185351 |
| 出典データセット | uspto-grants-1993_02 |
| ORD ID | ord-ef255aa7d83943e58570b79335d52856 |
| 出典メモ | uspto-grants-1993_02 |