Trifluoroacetic anhydride → Acetic acid, trifluoro-, (methylnitroamino)methyl ester

HRID 2081920ノート

反応式

HRID 2081920 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]([O:5][C:6](=O)C(F)(F)F)=[O:4].O[CH2:15][N:16]([N+:18]([O-:20])=[O:19])C>ClCCl>[F:1][C:2]([F:13])([F:12])[C:3]([O:5][CH2:6][N:16]([N+:18]([O-:20])=[O:19])[CH3:15])=[O:4]

参加物

4

反応物 2

HCID 9845Trifluoroacetic anhydrideHCID 119262Methanol, (methylnitramino)-

生成物 1

HCID 13352131Acetic acid, trifluoro-, (methylnitroamino)methyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Trifluoroacetic anhydride (80 ml, 118.4 g, 0.56 moles) was added to a stirred solution of 1-hydroxy-2-nitro-2-azapropane (40.0 g, 0.38 moles) in dichloromethane (60 ml) at -5° to 0° C. during 11/2 hours. The resulting solution was then distilled without warming at 20 mm, then to 3 mm. The product was distilled at 1.5 mm, 65° C., to give 2-nitro-2-azapropyl trifluoroacetate; yield: 48 g (63%).

後処理

  1. distillationThe resulting solution was then distilled
  2. temperaturewithout warming at 20 mm
  3. distillationThe product was distilled at 1.5 mm, 65° C.

出典と根拠

ORDレコード
ord-7d85e6541fa64edb93056774a4eb11f3
出典データセット
uspto-grants-1993_02
特許番号
US05186770

反応ノート

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