Isatoic Anhydride → HCID 13365992、化合物

HRID 2082139ノート

反応式

HRID 2082139 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[N:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH2:7][CH2:6]1.[C:17]12[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=1)[NH:22]C(=O)O[C:18]2=[O:19].C(OCC)(=O)C>CN(C)C=O.O>[N:16]1[CH:15]=[CH:14][CH:13]=[N:12][C:11]=1[N:8]1[CH2:7][CH2:6][N:5]([CH2:4][CH2:3][CH2:2][NH:1][C:18](=[O:19])[C:17]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[NH2:22])[CH2:10][CH2:9]1

参加物

6

反応物 3

HCID 8359Isatoic AnhydrideHCID 8857Ethyl AcetateHCID 107042273-(4-Pyrimidin-2-ylpiperazin-1-yl)propan-1-amine

生成物 1

HCID 13365992HCID 13365992、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

0.02 mol of 1-(3-aminopropyl)-4-(2-pyrimidinyl)piperazine is dissolved in 100 ml of absolute dimethylformamide, 0.02 mol of isatoic anhydride is added, and the mixture is stirred for 1 hour. It is diluted with 50 ml of water, shaken with ethyl acetate and the organic phase is evaporated. Purification is by column chromatography over silica gel 60. After elution with methylene chloride/methanol 93:7, the resulting oil can be crystallised from ethyl acetate with isopropyl ether.

後処理

  1. customthe organic phase is evaporated
  2. customPurification
  3. washAfter elution with methylene chloride/methanol 93:7
  4. customthe resulting oil can be crystallised from ethyl acetate with isopropyl ether

出典と根拠

ORDレコード
ord-98824a1aa9d64cd99dfc627f8dc93b0a
出典データセット
uspto-grants-1993_02
特許番号
US05187276

反応ノート

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