Piperazine → 5-Iodo-2-(piperazin-1-yl)pyrimidine
反応式
Cl[C:2]1[N:7]=[CH:6][C:5]([I:8])=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>CN(C)C=O>[I:8][C:5]1[CH:4]=[N:3][C:2]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:7][CH:6]=1参加物
4
実験手順
0.02 mol of 2-chloro-5-iodopyrimidine, 0.06 mol of piperazine and 100 ml of absolute dimethylformamide are heated to 100° for 45 minutes and then evaporated. The crystalline residue is shaken with potassium bicarbonate solution and methylene chloride. The substance contained in the methylene chloride phase is purified by column chromatography over silica gel 60. The amine obtained by elution with methylene chloride/methanol (7:3) is stirred with isopropyl ether and filtered off with suction.
後処理
- customevaporated
- customis purified by column chromatography over silica gel 60
出典と根拠
- ORDレコード
- ord-5f1ca74c94964d0d97b18d5811328ea6
- 出典データセット
- uspto-grants-1993_02
- 特許番号
- US05187276
反応ノート
読み込み中…